Skip to main content

Ageing or aging?

‘I decided I don’t mind being old. It’s relaxing.’  

A brilliant quote from my most excellent friend VH. 


I still can’t work out why the spelling of this word is different on the east versus the west of the Atlantic Ocean....anyway.... There are so many advantages to becoming older, and our societies should be keen to exploit the benefits as our populations skew to reach the bigger birthdays. Maybe the Queen will have to raise the age at which a birthday message is received, as many more people reach their 100th year.

Of course our work is principally to do with how the body changes as we age, but is it correct to define everything we see as different as potentially detrimental? When I compare an old brain mitochondrial proteome to that from a young brain is it fair to say that the proteins that are changed throughout life are necessarily associated with declining health?

This week Damien Hirst spoke in theGuardian’s culture podcast about Mr. Barnes a man who lived next door and collected things, providing inspiration and materials for the artist’s first collages. At the end of the article Hirst writes about visiting Louise Bourgeois towards the end of her life, how everything around her was old and crumbling. He hints at her environment being filled with character and the important imperfections requisite for something to be interesting. He thinks these features may have brought her comfort and that this might be a feature of getting older.

It made me think - what if the molecular ‘imperfections’ we see in the brain and other tissues are the echo of the same force at play? Is it the biochemistry we are revealing that makes older people so very interesting?

Comments

Popular posts from this blog

New research by a Nottingham academic linking the neurodegenerative disease Parkinson’s to changes in a protein in brain mitochondria is to receive support from a prestigious US funding agency. Dr Lisa Chakrabarti, at The University of Nottingham, will receive $75,000 for a one-year research project from The Michael J. Fox Foundation for Parkinson’s Research (MJFF), which is dedicated to finding a cure for Parkinson’s and funds promising research that could result in new treatments to slow, stop or reverse the progression of the disease. Dr Chakrabarti said: “We are trying to look at mitochondrial biology from a totally different perspective, which could have important implications for Parkinson’s and other neurodegenerative diseases. The funding from The Michael J. Fox Foundation will help us to confirm whether some of the protein changes we see in Parkinson’s are related to disease course.” http://exchange.nottingham.ac.uk/research/parkinsons-study-receives-fu...

Some impressions from the expedition

 

Katie and Jacob presented their work at the European Drosophila Research Conference in Alicante - September 25th-28th 2025

EDRC 2025 Alicante   Using a CaFe assay to assess mitochondrial function in olanzapine treated D.melanogaster.  Katherine Mortimer  'The EDRC 2025 brought together researchers from a diverse range of disciplines with a shared interest in using Drosophila melanogaster as a biological model. For that reason, I thoroughly enjoyed the poster session. I had lots of interesting conversations pertaining to all areas of my poster, from specific methodology to a general interest in mitochondria. I found myself chatting to people for the whole 2-hour session and walking away with lots of useful insights and connections. ' Quantum Sensing of Mitochondrial Physiology in Response to a Hypomagnetic Field. Jacob Reed 'It was great to be surrounded by researchers from around the world at the 28th EDRC, all sharing a passion for Drosophila. I especially enjoyed the talks on metabolism and mitochondria, which led to insightful conversations on mito-nuclear DNA mismatch. Presentin...