Lisa's Lab Book

Cell protein offers new hope in fighting the effects of aging Our new paper is out today in the journal Aging

FENS Forum  July2-6th 2016 Copenhagen Ha, better late than never here is an update of our presentations (and sightseeing) while at the FENS forum this year. Four of us were able to go James, Tom, Amelia and Myself (thank-you Biochemical Society for my award) and we took three posters along with us.  James Freed presenting our eicosanoids in Parkinson's disease poster Tom Ingram presenting work on epigenetic regulation in Parkinson's disease The Opera house Amelia Pollard presenting Mitochondrial ageing- lipidomics and proteomics  

Mitochondrial Complex 1 Activity Measured by Spectrophotometry Is Reduced across All Brain Regions in Ageing and More Specifically in Neurodegeneration. It is a busy time and also fun! We have another paper out this month in PLOS ONE. Congratulations to Amelia and Emma who are co-authors on this one. You can 'read all about it' here .  

Running Down Dementia - ARUK Last Saturday I addressed our local Colwick Parkrun to recruit runners to get involved with Alzheimer's Research UK 'Running Down Dementia'  scheme for the summer. Run 100K over the summer and raise £100! Love Parkrun #syatb!

I just want to say Thank-You to the Biochemical Society for sponsoring my attendance at FENS in Copenhagen July 2-6th 2016.

Our new paper... Analysis of Mitochondrial haemoglobin in Parkinson's disease brain. Mitochondrial dysfunction is an early feature of neurodegeneration. We have shown there are mitochondrial haemoglobin changes with age and neurodegeneration. We hypothesised that altered physiological processes are associated with recruitment and localisation of haemoglobin to these organelles. To confirm a dynamic localisation of haemoglobin we exposed Drosophila melanogaster to cyclical hypoxia with recovery. With a single cycle of hypoxia and recovery we found a relative accumulation of haemoglobin in the mitochondria compared with the cytosol. An additional cycle of hypoxia and recovery led to a significant increase of mitochondrial haemoglobin (p$_amp_$lt;0.05). We quantified ratios of human mitochondrial haemoglobin in 30 Parkinson's and matched control human post-mortem brains. Relative mitochondrial/cytosolic quantities of haemoglobin were obtained for the cortical re...

Come and learn some more about science directly from the experts!   A University of Nottingham Hermes Fellowship awarded to Matthew Young and Lisa C  has helped to fund a range of talks as part of a 'Pint of Science' festival in Nottingham from 23-25th of May 2016 Learn about neuroscience, space, food, engineering and lots more in pubs and bars around the city.